Piracetam reverses haloperidol-induced catalepsy in mice
نویسندگان
چکیده
Results: Th e administration of haloperidol (2 mg/kg, IP) resulted in signifi cant catalepsy. Piracetam (in dosages of 50, 100, and 300 mg/kg) given IP at the time of haloperidol administration reduced the duration of catalepsy by 24.4%, 32.3%, and 48.2%, respectively. Piracetam given as a 30-min pretreatment reduced the duration of catalepsy by 59.5%, 72.3%, and 78.2%, respectively. Vinpocetine coadministered IP with haloperidol did not modify catalepsy, but given as a 30-min pretreatment, the drug increased catalepsy duration by 53.5%, 53.6%, and 65.1%, respectively. Ginkgo biloba coadministered IP with haloperidol at 25, 50, or 150 mg/kg increased catalepsy duration by 13.6%-17.1%. Ginkgo biloba given 30 min prior to haloperidol increased catalepsy duration by 29.1%, 35.1%, and 37.2%, respectively.
منابع مشابه
Nootropic activity of tuber extract of Pueraria tuberosa (Roxb).
Nootropic effect of alcoholic (ALE; 50, 75, 100 mg/kg) and aqueous (AQE; 100, 200, 400 mg/kg) extracts of P. tuberosa was evaluated by using Elevated Plus Maze (EPM), scopolamine-induced amnesia (SIA), diazepam-induced amnesia (DIA), clonidine-induced (NA-mediated) hypothermia (CIH), lithium-induced (5-HT mediated) head twitches (LIH) and haloperidol-induced (DA- mediated) catalepsy (HIC) model...
متن کاملEffect of Tribulus terrestris on Haloperidol-induced Catalepsy in Mice
Haloperidol, an antipsychotic drug, leads to the development of a behavioural state called catalepsy, in which the animal is not able to correct an externally imposed posture. In the present study we have attempted to evaluate the anticataleptic effect of Tribulus terrestris on haloperidol-induced catalepsy in albino mice. Mice were allocated to four groups, each group containing six animals. B...
متن کاملCannabidiol attenuates catalepsy induced by distinct pharmacological mechanisms via 5-HT1A receptor activation in mice
Cannabidiol (CBD) is a non-psychotomimetic compound from Cannabis sativa plant that produces antipsychotic effects in rodents and humans. It also reverses L-dopa-induced psychotic symptoms and improves motor function in Parkinson's patients. This latter effect raised the possibility that CBD could have beneficial effects on motor related striatal disorders. To investigate this possibility we ev...
متن کاملTolerance and reverse tolerance to haloperidol catalepsy induced by the difference of administration interval in mice.
متن کامل
Neurobehavioral Effects of Phoenix dactylifera in Mice
The present study deals with the investigation of the neurobehavioral effects of the methanolic extract of Phoenix dactylifera (PD) fruits, studied on locomotor activity, exploratory behavior, motor coordination, hot-plate test, haloperidol-induced catalepsy, sodium nitriteinduced respiratory arrest, maximum electroshockinduced convulsions using mice. The results revealed that the extract in ...
متن کامل